PARP inhibitors for the treatment of ovarian cancer


Podcast 2021034

Questions:

  1. Which is the mechanism of action of PARP inhibitors and why this is relevant in ovarian cancer?
  2. How can we measure the homologous recombination deficiency?
  3. Which is the current evidence for the use of maintenance PARP inhibitors in recurrent epithelial ovarian cancer?
  4. Can you tell us which are the results of phase 3 trials that have investigated PARP inhibitors in front line treatment of epithelial ovarian cancer?
  5. Which are the main toxicities of PARP inhibitors?
Expert
Ilaria Colombo'
Medical oncologist
Oncology Institute of Southern Switzerland (IOSI)
Bellinzona, Switzerland